Mauricio Pochettino is yet to decide whether Christian Eriksen will start for Tottenham in their Champions League game with PSV on Wednesday.
But the Denmark international may be benched again when Spurs take on PSV in Group B, with both teams yet to win a point after two rounds of games.
“I think Danny Rose, Dele Alli and Jan Vertonghen are still out,” Pochettino told reporters.
“Christian Eriksen is fit to be selected and we’ll see tomorrow if he to play from the start of the game or from the bench.”
“I think it’s a big challenge for different reasons,” Pochettino added. “Of course I think it’s natural for us to try to put all our power and all our quality to try to manage in the best way.
“The situations that happen in the summer with the World Cup with not too much holidays and then you start to compete. For us it’s a massive, massive challenge because all the things that happened in the start of the season are different to the start of the last one.
“It’s true that it’s difficult to always feel like you’re playing away from home. We’re managing things that sure in the future will be completely different. When I signed my new contract we expected a tough period, but it is tougher than we believe.”
“He’s doing really well, it’s not normal to be so long at a top club,” Van Bommel told reporters “He’s doing a really good job. He did a good job at Southampton before.