Barcelona will be hoping that Luis Suarez can fill the sizeable goalscoring boots of the injured Lionel Messi when Inter visit Camp Nou on Wednesday.
Buoyed by their last-gasp derby win over AC Milan at the weekend, Luciano Spalletti’s side will need to reverse recent history if they are to leave Spain triumphant with Barca unbeaten in 13 games at home against Italian opposition.
Edinson Cavani faces off against his old side Napoli for the first time as Paris Saint-Germain look to beat an Italian side in the Champions League for the first time, while Tottenham are aiming to get their European campaign back on track against PSV.
Barcelona v Inter
13 – Barcelona are unbeaten in their last 13 Champions League home games against Italian sides (W10 D3), since a 2-1 loss against Juventus in April 2003.
Club Brugge v Monaco
12 – Club Brugge are without a clean sheet in their last 12 home Champions League games (W3 D2 L7), since a 0-0 draw against Lokomotiv Moscow in September 2002.
Paris Saint-Germain v Napoli
104 – If he plays, this will be Edinson Cavani’s first appearance against Napoli since he left the club in 2013 – the Uruguayan scored 104 goals in 138 games in all competitions for the Italian side.
Liverpool v Red Star Belgrade
18 – Since the start of last season, no player has been directly involved in more Champions League goals than Liverpool’s Roberto Firmino (18 – 11 goals, seven assists; level with Juventus’ Cristiano Ronaldo).
PSV v Tottenham
3 – Spurs have lost their last three European matches, all in the Champions League – they have never lost four consecutive major European matches in a row.
Lokomotiv Moscow v Porto
0 – Lokomotiv are one of only three sides yet to score in this season’s Champions League (also Valencia and Young Boys). Only one Russian side has ever failed to score in each of their first three games, Spartak Moscow doing so in 2002-03.
Borussia Dortmund v Atletico Madrid
25 – Since his Champions League debut for Atletico Madrid in September 2014, Antoine Griezmann has had a hand in 25 goals (19 goals, six assists), 15 more than any other Atletico player.
Galatasaray v Schalke
1 – Galatasaray have kept just one clean sheet in their last 16 Champions League games (33 goals conceded), although that was in their last home game in the tournament against Lokomotiv Moscow in September.